全文获取类型
收费全文 | 38066篇 |
免费 | 3734篇 |
国内免费 | 2597篇 |
专业分类
耳鼻咽喉 | 200篇 |
儿科学 | 495篇 |
妇产科学 | 564篇 |
基础医学 | 4805篇 |
口腔科学 | 688篇 |
临床医学 | 4585篇 |
内科学 | 6092篇 |
皮肤病学 | 349篇 |
神经病学 | 2311篇 |
特种医学 | 1301篇 |
外国民族医学 | 23篇 |
外科学 | 4200篇 |
综合类 | 5780篇 |
现状与发展 | 12篇 |
一般理论 | 3篇 |
预防医学 | 2160篇 |
眼科学 | 985篇 |
药学 | 3997篇 |
14篇 | |
中国医学 | 1903篇 |
肿瘤学 | 3930篇 |
出版年
2024年 | 32篇 |
2023年 | 512篇 |
2022年 | 723篇 |
2021年 | 1488篇 |
2020年 | 1375篇 |
2019年 | 1217篇 |
2018年 | 1302篇 |
2017年 | 1198篇 |
2016年 | 1143篇 |
2015年 | 1771篇 |
2014年 | 2096篇 |
2013年 | 1834篇 |
2012年 | 2927篇 |
2011年 | 3073篇 |
2010年 | 1860篇 |
2009年 | 1492篇 |
2008年 | 2101篇 |
2007年 | 2119篇 |
2006年 | 1946篇 |
2005年 | 2046篇 |
2004年 | 1396篇 |
2003年 | 1331篇 |
2002年 | 1083篇 |
2001年 | 879篇 |
2000年 | 1017篇 |
1999年 | 1067篇 |
1998年 | 623篇 |
1997年 | 670篇 |
1996年 | 501篇 |
1995年 | 483篇 |
1994年 | 439篇 |
1993年 | 298篇 |
1992年 | 313篇 |
1991年 | 326篇 |
1990年 | 289篇 |
1989年 | 250篇 |
1988年 | 217篇 |
1987年 | 208篇 |
1986年 | 180篇 |
1985年 | 136篇 |
1984年 | 100篇 |
1983年 | 78篇 |
1982年 | 32篇 |
1981年 | 43篇 |
1980年 | 28篇 |
1979年 | 32篇 |
1978年 | 25篇 |
1977年 | 19篇 |
1976年 | 18篇 |
1973年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
991.
Mu J Jiang G Brady E Dallas-Yang Q Liu F Woods J Zycband E Wright M Li Z Lu K Zhu L Shen X Sinharoy R Candelore ML Qureshi SA Shen DM Zhang F Parmee ER Zhang BB 《Diabetologia》2011,54(9):2381-2391
992.
Wei-Zhone Zhang Jue-Xing Xie Tie Shen Feng Lin Department of Surgery Taizhou First People''''s Hospital Taizhou China 《Hepatobiliary & Pancreatic Diseases International》2006,(3)
BACKGROUND: There is no report on case of severe acute hyperlipidemic pancreatitis after treatment of Sheehan's syndrome. METHODS: A 32-year-old female patient was diagnosed as having acute hyperlipidemic pancreatitis after treatment of Sheehan's syndrome, and treated with diet and lipidlowering agents in early stage. RESULTS: Abdominal pain and fever of the patient resolved within a few days. She was subjected to diet and oral lipid-lowering therapy on the 4th day after admission. The disease did not recur during the follow-up for more than one year. CONCLUSIONS: Estrogen replacement therapy should be prescribed for Sheehan's syndrome. The serum level of triglyceride should be monitored and treatment should be given to prevent severe acute pancreatitis. Lipid-lowering therapy in early stage is the key step towards a complete recovery. 相似文献
993.
细小病毒非结构蛋白基因转染人人低分化胃癌细胞株MKN.45后诱导其表达。研究发现该基因的表达能明显影响MKN-45细胞的生物特性。表现为部分细胞脱落死亡;存活细胞间粘附力增强;细胞倍增时间延长;细胞形态变圆、胞浆丰富,核/浆比例缩小;体外克隆形成率及裸小鼠体内成瘤能力下降。提示:1.转染的细小病毒非结构蛋白基因能在胃癌细胞内诱导表达。2.非结构蛋白基因表达对部分胃癌细胞具有直接细胞毒作用。3.该基因表达能干扰胃癌细胞生长,可能影响细胞增殖和分化过程而改变胃癌细胞的一些生长特征。 相似文献
994.
Xiao Shen Jing Sun Jingzhu Zhang Lu Ke Zhihui Tong Gang Li Wei Jiang Weiqin Li Jieshou Li 《Medicine》2015,94(28)
The incidence of acute bleeding is reported to be 13.5% in patients with acute necrotizing pancreatitis. However, of all the bleeding events, intra-abdominal bleeding was less studied in the literature and its risk factors have not been well defined yet. The purpose of the present study was to investigate the risk factors for massive intra-abdominal bleeding among the patients with infected necrotizing pancreatitis and assessed the outcome of these patients.Both univariate and multivariate logistic regression models were applied for evaluating risk factors for intra-abdominal bleeding using 33 indices, including age, sex, etiology of acute pancreatitis (AP), APACHE II score, etc. Outcome assessments such as mortality, hospital and intensive care unit (ICU) durations, and cost were also compared between patients with or without intra-abdominal bleeding.Acute kidney injury (AKI) (odds ratio [OR]: 7.54, 95% confidence interval [CI]: 2.53–22.52, P < 0.001) and number of operation (OR: 8.84, 95% CI: 2.01–38.86, P = 0.004) were 2 predictors for massive intra-abdominal bleeding in the patients with infected necrotizing pancreatitis. In addition, AP patients with intra-abdominal bleeding also showed significantly higher mortality rate, prolonged hospital and ICU durations, more complications and invasive treatments, as well as increased cost.Our study revealed that AKI and multiple operations were 2 critical factors increasing the risk of intra-abdominal bleeding among patients with infected necrotizing pancreatitis. Additionally, massive intra-abdominal bleeding was also associated with poor prognosis. 相似文献
995.
996.
患者女性,54岁。1998年9月因胸闷,心悸6年来院就诊,诊断为病态窦房结综合征,行双腔起搏器植入。起搏器型号为Biotronik Actors D,心房导线型号PX53-JUP,心室导线型号PX60-UP,当时心房导线采用右锁骨下静脉穿刺植入,心室导线采用右头静脉径路,术中测试心房起搏阈值0.4V、电流0.7mA。 相似文献
997.
Xu SP Sun GP Shen YX Wei W Peng WR Wang H 《World journal of gastroenterology : WJG》2007,13(2):250-256
AIM To investigate the antiproliferative effect of paeonol (Pae) used alone or in combination with chemotherapeutic agents [cisplatin (CDDP), doxorubicin (DOX) and 5-fluorouracil (5-FU)] on human hepatoma cell line HepG2 and the possible mechanisms.METHODS The cytotoxic effect of drugs on HepG2 cells was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetra-zolium bromide (MTT) assay.Morphologic changes were observed by acridine orange (AO) fluorescence staining. Cell cycle and apoptosis rate were detected by flow cytometry (FCM). Drug-drug interactions were analyzed by the coefficient of drug interaction (CDI).RESULTS Pae (7.81-250 mg/L) had an inhibitory effect on the proliferation of HepG2 cells in a dose-dependent manner, with the IC50 value of (104.77 7.28) mg/L. AO fluorescence staining and FCM assays showed that Pae induced apoptosis and arrested cell cycle at S phase in HepG2 cells. Further, different extent synergisms were observed when Pae (15.63, 31.25, 62.5 mg/L) was combined with CDDP (0.31-2.5 mg/L), DOX (0.16-1.25 mg/L), or 5-FU (12.5-100 mg/L) at appropriate concentrations. The IC50 value of the three drugs decreased dramatically when combined with Pae (P <0.01). Of the three different combinations, the sensitivity of cells to drugs was considerably different.CONCLUSION Pae had a significant growth-inhibitory effect on the human hepatoma cell line HepG2,which may be related to apoptosis induction and cell cycle arrest. It also can enhance the cytotoxicity of chemotherapeutic agents on HepG2 cells, and the S phase arrest induced by Pae may be one of the mechanisms of these interactions. 相似文献
998.
Presentation of ovalbumin internalized via the immunoglobulin-A Fc receptor is enhanced through Fc receptor gamma-chain signaling 总被引:1,自引:0,他引:1 下载免费PDF全文
Shen L van Egmond M Siemasko K Gao H Wade T Lang ML Clark M van De Winkel JG Wade WF 《Blood》2001,97(1):205-213
The mechanism of enhanced presentation of ovalbumin (OVA)internalized as immunoglobulin A (IgA)-OVA via the IgA Fc receptor (FcR) was analyzed by focusing on the role of the FcR-associated chain. Comparison of B-cell transfectants expressing FcR plus wild-type (WT) chain or chain in which theimmunoreceptor tyrosine-based activation motif (ITAM) was altered bytyrosine mutation or substitution with the ITAM of FcRIIA showedthat signaling-competent ITAM was not required for endocytosis ofIgA-OVA. However, antigen presentation was impaired by ITAM changes.Signaling-competent -chain ITAM appeared necessary for transport ofligated FcR to a lamp-1+ late endocytic compartment forremodeling and/or activation of that compartment and also for efficientdegradation of IgA complexes. Moreover, FcR ligation also activatedefficient processing of nonreceptor-targeted antigen. Theresults suggest that -chain signaling activates the antigenprocessing compartment. 相似文献
999.
Fred Morady Mary Jane Sauve Patricia Malone Edward N. Shen Alan B. Schwartz Anil Bhandari Edmond Keung Ruey J. Sung Melvin M. Scheinman 《The American journal of cardiology》1983,52(8):975-979
Amiodarone was administered to 154 patients who had sustained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refractory to conventional antiarrhythmic drugs. The loading dose was 800 mg/day for 6 weeks and the maintenance dose was 600 mg/day. Sixty-nine percent of patients continued treatment with amiodarone and had no recurrence of symptomatic VT or ventricular fibrillation (VF) over a follow-up of 6 to 52 months (mean ± standard deviation 14.2 ± 8.2). Six percent of the patients had a nonfatal recurrence of VT and were successfully managed by continuing amiodarone at a higher dose or by the addition of a conventional antiarrhythmic drug. One or more adverse drug reactions occurred in 51% of patients. Adverse effects forced a reduction in the dose of amiodarone in 41 % and discontinuation of amiodarone in 10% of patients. The most common symptomatic adverse reactions were tremor or ataxia (35 %), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormalities (6%) and pulmonary interstitial infiltrates (5%).Although large-dose amiodarone is highly effective in the long-term treatment of VT or VF refractory to conventional antiarrhythmic drugs, it causes significant toxicity in approximately 50% of patients. However, when the dose is adjusted based on clinical response or the development of adverse effects, 75 % of patients with VT or VF can be successfully managed with amiodarone. 相似文献
1000.